| First Author | Suto F | Year | 2003 |
| Journal | Mech Dev | Volume | 120 |
| Issue | 3 | Pages | 385-96 |
| PubMed ID | 12591607 | Mgi Jnum | J:82114 |
| Mgi Id | MGI:2451188 | Doi | 10.1016/s0925-4773(02)00421-5 |
| Citation | Suto F, et al. (2003) Identification and characterization of a novel mouse plexin, plexin-A4. Mech Dev 120(3):385-96 |
| abstractText | Plexins belonging to the plexin-A subfamily form complexes with neuropilins and propagate signals of class 3 semaphorins into neurons, even though they do not directly bind the semaphorins. In this study, we identified a new member of the plexin-A subfamily in the mice, plexin-A4, and showed that it was expressed in the developing nervous system with a pattern different to that of other members of the plexin-A subfamily (plexin-A1, plexin-A2 and plexin-A3). COS-7 cells coexpressing plexin-A4 with neuropilin-1 were induced to contract by Sema3A, a member of the class 3 semaphorin. Ectopic expression of plexin-A4 in mitral cells that are originally insensitive to Sema3A resulted in the collapse of growth cones in the presence of Sema3A. These results suggest that plexin-A4 plays a role in the propagation of Sema3A activities. |
