| First Author | Kishimoto Y | Year | 2012 |
| Journal | Neurosci Lett | Volume | 506 |
| Issue | 1 | Pages | 155-9 |
| PubMed ID | 22085694 | Mgi Jnum | J:180385 |
| Mgi Id | MGI:5306188 | Doi | 10.1016/j.neulet.2011.10.071 |
| Citation | Kishimoto Y, et al. (2012) Impaired long-trace eyeblink conditioning in a Tg2576 mouse model of Alzheimer's disease. Neurosci Lett 506(1):155-9 |
| abstractText | Eyeblink conditioning has been used for assessing cognitive performance in cases of human neurodegenerative diseases including Alzheimer's disease (AD). Here, we tested and compared the delay and long-trace interval (TI=500ms) eyeblink conditionings in a Tg2576 mouse model of AD, at the age of 3, 6, and 12 months. Tg2576 mice exhibited significant impairment in trace conditioning at 6 months of age. In contrast, delay conditioning was not impaired in Tg2576 mice even at 12 months. These findings indicate that the long-TI eyeblink conditioning is more susceptible to age-related cognitive deterioration than delay conditioning in Tg2576 mice. The long-trace eyeblink conditioning could be a potential tool for detecting early cognitive deficits in AD mouse model. |
