First Author | Baxter AG | Year | 2005 |
Journal | Int Rev Immunol | Volume | 24 |
Issue | 1-2 | Pages | 55-62 |
PubMed ID | 15763989 | Mgi Jnum | J:97908 |
Mgi Id | MGI:3576642 | Doi | 10.1080/08830180590884404 |
Citation | Baxter AG, et al. (2005) Genetic control of susceptibility to autoimmune gastritis. Int Rev Immunol 24(1-2):55-62 |
abstractText | A familial component to the tendency to develop autoimmune gastritis has long been recognized. Although linkage to certain HLA alleles and an association with the endocrine autoimmune diseases thyroiditis and type 1 diabetes have been reported, little further progress has been achieved in clinical studies. In contrast, the mouse model of gastritis induced in the BALB/c strain by thymectomy in the third day of life has identified four linkage regions; two on distal chromosome 4 (Gasa1 and Gasa2), one on chromosome 6 (Gasa3) and one in the H2 (Gasa4). Three of these four genes colocalize with NOD mouse diabetes susceptibility genes--the strongest concordance identified to date between any two autoimmune diseases--reflecting the association between autoimmune diabetes and type 1 gastritis in humans. |