| Type | MGI:General | Description | naïve CD4+ T cells stimulated in vitro through the TCR only have a third the proliferative response as control mice 66% fewer naive CD4+ T cells go into S-phase with 24 hours of TCR stimulation compared to controls the S-phase entry defect can be partly overcome by CD28 stimulation allogeneic proliferative response of naïve CD4+ T cells is reduced 6-fold compared to controls the amount of IL-2 required for a half maximal proliferation response is 100-fold higher than in controls |
