| First Author | Lai JJ | Year | 2012 |
| Journal | Am J Pathol | Volume | 181 |
| Issue | 5 | Pages | 1504-12 |
| PubMed ID | 22959669 | Mgi Jnum | J:190143 |
| Mgi Id | MGI:5448121 | Doi | 10.1016/j.ajpath.2012.07.008 |
| Citation | Lai JJ, et al. (2012) Androgen receptor influences on body defense system via modulation of innate and adaptive immune systems: lessons from conditional AR knockout mice. Am J Pathol 181(5):1504-12 |
| abstractText | Upon insult, such as infection or tissue injury, the innate and adaptive immune systems initiate a series of responses to defend the body. Recent studies from immune cell-specific androgen receptor (AR) knockout mice demonstrated that androgen and its receptor (androgen/AR) play significant roles in both immune regulations. In the innate immunity, androgen/AR is required for generation and proper function of neutrophils; androgen/AR also regulates wound healing processes through macrophage recruitment and proinflammatory cytokine production. In adaptive immunity, androgen/AR exerts suppressive effects on development and activation of T and B cells. Removal of such suppression causes thymic enlargement and excessive export of immature B cells. Altogether, androgen/AR plays distinct roles in individual immune cells, and targeting androgen/AR may help in treatment and management of immune-related diseases. |
