| First Author | Ishiguro A | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 2 | Pages | 154-8 |
| PubMed ID | 18068128 | Mgi Jnum | J:130327 |
| Mgi Id | MGI:3771485 | Doi | 10.1016/j.febslet.2007.11.080 |
| Citation | Ishiguro A, et al. (2008) Functional role of Zic2 phosphorylation in transcriptional regulation. FEBS Lett 582(2):154-8 |
| abstractText | Zic2 is a transcriptional activator that plays a crucial role in mammalian forebrain development. It activates the transcription of target genes by DNA binding and recruitment of RNA helicase A (RHA). We recently reported that the Zic2-RHA interaction is decreased by phosphatase treatment in vitro. We have now identified the phosphorylation site (serine 200) in mouse Zic2. Zic2S200A was defective in RHA-binding, and its transcriptional activation ability was diminished. These data indicate that Zic2S200 is a target for phosphorylation by DNA-dependent protein kinase, regulating Zic2-mediated transcriptional activation. |
