| First Author | Parkinson DB | Year | 2008 |
| Journal | J Cell Biol | Volume | 181 |
| Issue | 4 | Pages | 625-37 |
| PubMed ID | 18490512 | Mgi Jnum | J:137068 |
| Mgi Id | MGI:3797706 | Doi | 10.1083/jcb.200803013 |
| Citation | Parkinson DB, et al. (2008) c-Jun is a negative regulator of myelination. J Cell Biol 181(4):625-37 |
| abstractText | Schwann cell myelination depends on Krox-20/Egr2 and other promyelin transcription factors that are activated by axonal signals and control the generation of myelin-forming cells. Myelin-forming cells remain remarkably plastic and can revert to the immature phenotype, a process which is seen in injured nerves and demyelinating neuropathies. We report that c-Jun is an important regulator of this plasticity. At physiological levels, c-Jun inhibits myelin gene activation by Krox-20 or cyclic adenosine monophosphate. c-Jun also drives myelinating cells back to the immature state in transected nerves in vivo. Enforced c-Jun expression inhibits myelination in cocultures. Furthermore, c-Jun and Krox-20 show a cross-antagonistic functional relationship. c-Jun therefore negatively regulates the myelinating Schwann cell phenotype, representing a signal that functionally stands in opposition to the promyelin transcription factors. Negative regulation of myelination is likely to have significant implications for three areas of Schwann cell biology: the molecular analysis of plasticity, demyelinating pathologies, and the response of peripheral nerves to injury. |
