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Protein Coding Gene : Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

Primary Identifier  MGI:2384589 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  235439
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0)

Acts upstream of or within negative regulation of autophagy; nervous system development; and neuromuscular process controlling balance. Is expressed in several structures, including jaw bone; nervous system; sensory organ; thymus primordium; and vibrissa. Orthologous to human HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1).
PHENOTYPE: Homozygotes for this spontaneous mutation exhibit an abnormal cerebellar Purkinje cell layer and Purkinje cell degeneration. [provided by MGI curators]
  • synonyms:
  • 2810449H11Rik,
  • MGI:1925757,
  • MGI:2442235,
  • MGI:3613032,
  • RIKEN cDNA 2810449H11 gene,
  • D130015N03Rik,
  • tbl,
  • Herc1,
  • RIKEN cDNA D130015N03 gene,
  • MGC:7618,
  • tambaleante,
  • HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

4 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For