| First Author | Seki T | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 12152 | PubMed ID | 27492130 |
| Mgi Jnum | J:240338 | Mgi Id | MGI:5883162 |
| Doi | 10.1038/ncomms12152 | Citation | Seki T, et al. (2016) Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat. Nat Commun 7:12152 |
| abstractText | Cold- and beta3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of endothelial VEGFR2, knockout of the Pdgf-c gene or pharmacological blockade of PDGFR-alpha impair the WAT-beige transition. We further show that PDGF-CC stimulation upregulates UCP1 expression and acquisition of a beige phenotype in differentiated mouse WAT-PDGFR-alpha(+) progenitor cells, as well as in human WAT-PDGFR-alpha(+) adipocytes, supporting the physiological relevance of our findings. Our data reveal a paracrine mechanism by which angiogenic endothelial cells modulate adipocyte metabolism, which may provide new targets for the treatment of obesity and related metabolic diseases. |
