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Allele : Pole<em3Ewht> polymerase (DNA directed), epsilon; endonuclease-mediated mutation 3, Eileen White

Primary Identifier  MGI:7797733 Allele Type  Endonuclease-mediated
Attribute String  Conditional ready Gene  Pole
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  Using CRISPR technology, a sgRNA (AGTGGAGGCTCAAGTGGCAT) was designed to target the Pole gene to introduce Lox-Stop-Lox cassette and a GTT to CTT mutation in exon 13 resulting in a valine to leucine change at amino acid 411 (V411L).
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • LSL-Pole V411L,
  • LSL-Pole V411L
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

2 Publication categories

Trail: Allele