Primary Identifier | MGI:4460818 | Allele Type | Targeted |
Attribute String | Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter | Gene | Gt(ROSA)26Sor |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A cDNA for the fusion of human ITK-SYK, which is preceded by a splice acceptor and floxed neo cassette and followed by an IRES-eGFP and polyadenylation sequence, was inserted into the locus. Cre mediated recombination is required to induce expression of the fusion cDNA. This fusion was identified peripheral T cell lymphoma patients with the chromosomal translocation t(5;9)(q33;p22). |