| Primary Identifier | MGI:99150 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 22632 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including DNA metabolic process; regulation of nucleobase-containing compound metabolic process; and response to UV-C. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including RNA localization; camera-type eye morphogenesis; and regulation of gene expression. Located in nucleus. Part of chromatin; nucleus; and transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; eye; hemolymphoid system gland; and reproductive system. Used to study pleuropulmonary blastoma. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human YY1 (YY1 transcription factor). PHENOTYPE: Homozygous null mice die in utero shortly after implantation. Incomplete penetrance of embryonic growth retardation and exencephaly are observed in haploinsufficient mice. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
