| First Author | Stanfel MN | Year | 2006 |
| Journal | Genesis | Volume | 44 |
| Issue | 11 | Pages | 550-5 |
| PubMed ID | 17078065 | Mgi Jnum | J:114573 |
| Mgi Id | MGI:3689453 | Doi | 10.1002/dvg.20250 |
| Citation | Stanfel MN, et al. (2006) Expression of an Nkx3.1-CRE gene using ROSA26 reporter mice. Genesis 44(11):550-5 |
| abstractText | The genetic locus of Nkx3.1, an early murine marker of sclerotome and prostate development, was disrupted by a knock in of CRE recombinase via homologous recombination in embryonic stem cells. Cell fate mapping revealed previously unidentified cell lineages expanded from Nkx3.1-expressing cell populations and recapitulated reported Nkx3.1 expression patterns. In lineage trace experiments of E18.5 Nkx3.1-CRE; R26R embryos novel staining was observed in areas of the lungs, portions of the duodenum, and vertebral elements of the skeleton. beta-galactosidase activity measured in Nkx3.1-CRE; R26R and Nkx3.2-CRE; R26R embryos was observed in overlapping regions of the sclerotome but no apparent change in Nkx3.1 expression was seen in the Nkx3.2 mutants by in situ hybridization. genesis 44:550-555, 2006 Published 2006 Wiley-Liss, Inc. |
