| First Author | Akyol A | Year | 2008 |
| Journal | Nat Methods | Volume | 5 |
| Issue | 3 | Pages | 231-3 |
| PubMed ID | 18264107 | Mgi Jnum | J:148161 |
| Mgi Id | MGI:3843613 | Doi | 10.1038/nmeth.1182 |
| Citation | Akyol A, et al. (2008) Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene. Nat Methods 5(3):231-3 |
| abstractText | Strategies for altering constitutional or somatic genotype in mice are well established, but approaches to generate mosaic genotypes in mouse tissues are limited. We showed that a functionally inactive Cre recombinase transgene with a long mononucleotide tract altering the reading frame was stochastically activated in the mouse intestinal tract. We demonstrated the utility of this approach by inducing colonic polyposis after Cre-mediated bi-allelic inactivation of the Apc gene. |
