| First Author | Buza-Vidas N | Year | 2011 |
| Journal | Blood | Volume | 118 |
| Issue | 5 | Pages | 1291-3 |
| PubMed ID | 21670475 | Mgi Jnum | J:176922 |
| Mgi Id | MGI:5293192 | Doi | 10.1182/blood-2011-02-338046 |
| Citation | Buza-Vidas N, et al. (2011) GATA3 is redundant for maintenance and self-renewal of hematopoietic stem cells. Blood 118(5):1291-3 |
| abstractText | GATA3 has been identified as a master regulator of T helper cells, as well as being important for early thymic progenitors and T-cell commitment. However, Gata3 expression initiates already at the hematopoietic stem cell (HSC) level, implicating a potential role also in the regulation of HSCs. Herein we used a conditional Gata3 knockout strategy in which Gata3 expression was completely deleted from the earliest stage of embryonic hematopoietic development after emergence of HSCs from hemogenic endothelium. Through a detailed analysis of HSCs at the phenotypic and functional level, we demonstrate that steady-state levels of HSCs are normal in Gata3(fl/fl)Vav-Cre(tg/+) mice. Moreover, through long-term primary and secondary transplantation experiments, we also unequivocally demonstrate that Gata3 has a redundant role in post-transplantation HSC self-renewal. |
