|  Help  |  About  |  Contact Us

Allele : Tg(Tcrb)93Vbo transgene insertion 93, Harald von Boehmer
Primary Identifier  MGI:3056727 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Tcrb)93Vbo
Strain of Origin  (CBA/BrA x C57BL/LiA)F2 Is Recombinase  false
Is Wild Type  false
description  In transgenic mice, T lymphocytes express the transgene on cell surfaces while the protein products encoded by endogenous Tcrb genes are not expressed. Most homozygous transgenic mice do not survive beyond postnatal week four.
molecularNote  The transgene contains a rearranged genomic segment derived from the Tcrb locus, and was constructed from B6 (Tcrb-V8.2,Tcrb-D) and BALB/c (Tcrb-J, Tcrb-C) sequences. Over 98% of T cells express the transgenic TCR-beta chain in hemizygous mice. The rearranged beta-chain sequence was isolated from an anti-H-Y, H-2Db-restricted CD8+ T cell clone, B6.2.16.
  • mutations:
  • Insertion
  • synonyms:
  • Vbeta8.2<tg>,
  • TCRBbeta8.2,
  • TCRB TG,
  • TCRBbeta8.2,
  • TCRB TG,
  • HYbeta,
  • HYbeta,
  • Vbeta8.2<tg>
Paste the following link
Quick Links:
SummaryGenomePhenotypeOther
 
Quick Links:
SummaryGenomePhenotypeOther
 
Lists
This Allele isn't in any lists. Upload a list.

1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

30 Publication categories

Trail: Allele




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom