| First Author | Nadeau JH | Year | 2001 |
| Journal | Nat Rev Genet | Volume | 2 |
| Issue | 3 | Pages | 165-74 |
| PubMed ID | 11256068 | Mgi Jnum | J:88013 |
| Mgi Id | MGI:3028822 | Doi | 10.1038/35056009 |
| Citation | Nadeau JH (2001) Modifier genes in mice and humans. Nat Rev Genet 2(3):165-74 |
| abstractText | An emerging theme of studies with spontaneous, engineered and induced mutant mice is that phenotypes often depend on genetic background, implying that genetic modifiers have a role in guiding the functional consequences of genetic variation. Understanding the molecular and cellular basis by which modifier genes exert their influence will provide insights into developmental and physiological pathways that are critical to fundamental biological processes, as well as into novel targets for therapeutic interventions in human diseases. |
