| First Author | Iwai H | Year | 2012 |
| Journal | J Neuroimmunol | Volume | 250 |
| Issue | 1-2 | Pages | 1-8 |
| PubMed ID | 22652460 | Mgi Jnum | J:328400 |
| Mgi Id | MGI:6867897 | Doi | 10.1016/j.jneuroim.2012.05.007 |
| Citation | Iwai H, et al. (2012) Fetal thymus graft prevents age-related hearing loss and up regulation of the IL-1 receptor type II gene in CD4(+) T cells. J Neuroimmunol 250(1-2):1-8 |
| abstractText | We found that rejuvenation of the recipient immunity by inoculation of young CD4(+) T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II (IL-1R2) gene in CD4(+) T cells and reduced age-related hearing loss and degeneration of the spiral ganglion in SAMP1 mice, a murine model of human senescence. Our studies on the relationship between age-related systemic immune dysfunctions and neurodegeneration mechanisms open up new avenues of treatment of neurosenescence, including presbycusis, for which there is no effective therapy. |
