| Primary Identifier | IPR030675 | Type | Family |
| Short Name | BPI/LBP |
| description | This entry represents the bactericidal permeability-increasing protein (BPI) and the lipopolysaccharide-binding protein (LBP). The crystal structures of BPI and LBP are similar [], and they may represent a common gene family of lipid-binding proteins [].In mammals, LBP and BPI mediate the biological effects of LPS (lipopolysaccharide), a glycolipid present in the outer membrane of Gram-negative bacteria. LBP is a plasma protein that enhances the inflammatory response to LPS, whereas BPI is found in lysosomal granules of polymorphonuclear neutrophils, is bactericidal, and neutralises the toxic effects of LPS [, ]. LBP is an acute phase serum protein secreted mainly by the liver that modulates the LPS-induced immune response. LBP binds mainly to the lipid A moiety of LPS and acts as an affinity enhancer for CD14, facilitating its association with LPS []. |
