| First Author | Assmann N | Year | 2017 |
| Journal | Nat Immunol | Volume | 18 |
| Issue | 11 | Pages | 1197-1206 |
| PubMed ID | 28920951 | Mgi Jnum | J:305308 |
| Mgi Id | MGI:6706435 | Doi | 10.1038/ni.3838 |
| Citation | Assmann N, et al. (2017) Srebp-controlled glucose metabolism is essential for NK cell functional responses. Nat Immunol 18(11):1197-1206 |
| abstractText | Activated natural killer (NK) cells engage in a robust metabolic response that is required for normal effector function. Using genetic, pharmacological and metabolic analyses, we demonstrated an essential role for Srebp transcription factors in cytokine-induced metabolic reprogramming of NK cells that was independent of their conventional role in the control of lipid synthesis. Srebp was required for elevated glycolysis and oxidative phosphorylation and promoted a distinct metabolic pathway configuration in which glucose was metabolized to cytosolic citrate via the citrate-malate shuttle. Preventing the activation of Srebp or direct inhibition of the citrate-malate shuttle inhibited production of interferon-gamma and NK cell cytotoxicity. Thus, Srebp controls glucose metabolism in NK cells, and this Srebp-dependent regulation is critical for NK cell effector function. |
