| First Author | Freudenberg MA | Year | 2002 |
| Journal | J Immunol | Volume | 169 |
| Issue | 4 | Pages | 1665-8 |
| PubMed ID | 12165484 | Mgi Jnum | J:120706 |
| Mgi Id | MGI:3707671 | Doi | 10.4049/jimmunol.169.4.1665 |
| Citation | Freudenberg MA, et al. (2002) Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling. J Immunol 169(4):1665-8 |
| abstractText | IFN-alphabeta is a potent immunoregulatory cytokine involved in the defense against viral and bacterial infections. In this study, we describe an as yet undefined IFN-alphabeta-dependent pathway of IFN-gamma induction in mice. This pathway is based on a synergism of IFN-alphabeta and IL-18, and is independent of IL-12 signaling yet dependent on STAT4. In contradiction to current dogma, we show further that IFN-alphabeta alone induces tyrosine phosphorylation of STAT4 in murine splenocytes of different mouse strains. This pathway participates in the induction of IFN-gamma by Gram-negative bacteria and is therefore expected to play a role whenever IFN-alpha or IFN-beta and IL-18 are produced concomitantly during bacterial, viral, or other infections. |
