| First Author | Xu W | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 1 | Pages | 111987 |
| PubMed ID | 36640309 | Mgi Jnum | J:333439 |
| Mgi Id | MGI:7432254 | Doi | 10.1016/j.celrep.2022.111987 |
| Citation | Xu W, et al. (2023) GOT1 regulates CD8(+) effector and memory T cell generation. Cell Rep 42(1):111987 |
| abstractText | T cell activation, proliferation, function, and differentiation are tightly linked to proper metabolic reprogramming and regulation. By using [U-(13)C]glucose tracing, we reveal a critical role for GOT1 in promoting CD8(+) T cell effector differentiation and function. Mechanistically, GOT1 enhances proliferation by maintaining intracellular redox balance and serine-mediated purine nucleotide biosynthesis. Further, GOT1 promotes the glycolytic programming and cytotoxic function of cytotoxic T lymphocytes via posttranslational regulation of HIF protein, potentially by regulating the levels of alpha-ketoglutarate. Conversely, genetic deletion of GOT1 promotes the generation of memory CD8(+) T cells. |
