| First Author | Suh YH | Year | 1994 |
| Journal | J Neurochem | Volume | 63 |
| Issue | 5 | Pages | 1603-8 |
| PubMed ID | 7931317 | Mgi Jnum | J:21012 |
| Mgi Id | MGI:69063 | Doi | 10.1046/j.1471-4159.1994.63051603.x |
| Citation | Suh YH, et al. (1994) Complete nucleotide sequence and tissue-specific expression of the rat phenylethanolamine N-methyltransferase gene. J Neurochem 63(5):1603-8 |
| abstractText | The rat phenylethanolamine N-methyltransferase (PNMT) gene was isolated from a genomic library by cross-hybridization with a bovine PNMT cDNA probe. Complete nucleotide sequence analysis of a genomic clone showed that this gene contained three exons and spanned about 2.8 kb in length. There were the acute-phase response element, TATA, SP1, and GRE sequences. The physicochemical properties of rat adrenal PNMT were different from those of the brainstem PNMT. However, northern blot and reverse transcription-polymerase chain reaction analysis showed that the rat PNMT gene may not express the multiple forms of mRNA. These results suggest that the rat PNMT gene might produce a single enzyme protein, whose activity may be differentially modulated by tissue-specific environment in the central and peripheral systems. |
