| First Author | Strasser A | Year | 1999 |
| Journal | Eur J Immunol | Volume | 29 |
| Issue | 3 | Pages | 928-35 |
| PubMed ID | 10092097 | Mgi Jnum | J:115223 |
| Mgi Id | MGI:3691154 | Doi | 10.1002/(SICI)1521-4141(199903)29:03<928::AID-IMMU928>3.0.CO;2-P |
| Citation | Strasser A, et al. (1999) The transcriptional regulator Rel is essential for antigen receptor-mediated stimulation of mature T cells but dispensable for positive and negative selection of thymocytes and T cell apoptosis. Eur J Immunol 29(3):928-35 |
| abstractText | The family of Rel/NF-kappaB transcription factors is a crucial regulator of various cellular responses. Using Rel-deficient (c-rel-/-) mice crossed with T cell receptor (TCR)-transgenic mice we show that Rel is neither required for positive selection of major histocompatibility complex (MHC)-restricted T cells nor for deletion of thymocytes bearing autoreactive antigen receptors. Our studies also demonstrate that Rel is dispensable for T lymphocyte apoptosis. Rel is, however, essential for antigen-induced activation of mature T cells and its absence exacerbates the anergic state. These results indicate that thymocytes and mature T cells differ in their requirement for Rel in mediating TCR-induced responses. |
