| First Author | Shamah SM | Year | 2001 |
| Journal | Cell | Volume | 105 |
| Issue | 2 | Pages | 233-44 |
| PubMed ID | 11336673 | Mgi Jnum | J:69046 |
| Mgi Id | MGI:1933933 | Doi | 10.1016/s0092-8674(01)00314-2 |
| Citation | Shamah SM, et al. (2001) EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell 105(2):233-44 |
| abstractText | Eph receptors transduce short-range repulsive signals for axon guidance by modulating actin dynamics within growth cones. We report the cloning and characterization of ephexin, a novel Eph receptor-interacting protein that is a member of the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho GTPases. Ephrin-A stimulation of EphA receptors modulates the activity of ephexin leading to RhoA activation, Cdc42 and Rac1 inhibition, and cell morphology changes. In addition, expression of a mutant form of ephexin in primary neurons interferes with ephrin-A-induced growth cone collapse. The association of ephexin with Eph receptors constitutes a molecular link between Eph receptors and the actin cytoskeleton and provides a novel mechanism for achieving highly localized regulation of growth cone motility. |
