|  Help  |  About  |  Contact Us

Publication : Characterization of Ngef, a novel member of the Dbl family of genes expressed predominantly in the caudate nucleus.

First Author  Rodrigues NR Year  2000
Journal  Genomics Volume  65
Issue  1 Pages  53-61
PubMed ID  10777665 Mgi Jnum  J:61766
Mgi Id  MGI:1355568 Doi  10.1006/geno.2000.6138
Citation  Rodrigues NR, et al. (2000) Characterization of Ngef, a novel member of the Dbl family of genes expressed predominantly in the caudate nucleus. Genomics 65(1):53-61
abstractText  We have identified Ngef as a novel member of the family of Dbl genes. Many members of this family have been shown to function as guanine nucleotide exchange factors for the Rho-type GTPases. Ngef is predominantly expressed in brain, with the strongest signal in the caudate nucleus, a region associated with the control of movement. Ngef contains a translated trinucleotide repeat, a polyglutamic acid stretch interrupted by a glycine. We have localized the Ngef gene to mouse chromosome 1 and the human homologue of Ngef to human chromosome 2q37. We have shown in preliminary experiments that Ngef has transforming potential in cell culture and is able to induce tumors in nude mice. Copyright 2000 Academic Press.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

15 Bio Entities

Trail: Publication

11 Expression

Trail: Publication