| First Author | Wong S | Year | 2001 |
| Journal | Oncogene | Volume | 20 |
| Issue | 40 | Pages | 5644-59 |
| PubMed ID | 11607816 | Mgi Jnum | J:72276 |
| Mgi Id | MGI:2152240 | Doi | 10.1038/sj.onc.1204638 |
| Citation | Wong S, et al. (2001) Modeling Philadelphia chromosome positive leukemias. Oncogene 20(40):5644-59 |
| abstractText | The Ph chromosome has been genetically linked to CML and ALL. Its chimeric fusion gene product, BCR-ABL, can generate leukemia in mice. This review will discuss selected model systems developed to study BCR-ABL induced leukemia and focuses on what we have learned about the human disease from these models. Five main experimental approaches will be discussed including: (i) Reconstitution of mice with bone marrow cells retrovirally transduced with BCR-ABL; (ii) Transgenic mice expressing BCR-ABL; (iii) Knock-in mice with BCR-ABL expression driven from the endogenous bcr locus; (iv) Development of CML-like disease in mice with loss of function mutations in heterologous genes; and (v) ES in vitro hematopoietic differentiation coupled with regulated BCR-ABL expression. |
