| First Author | Weissman B | Year | 2009 |
| Journal | Cancer Res | Volume | 69 |
| Issue | 21 | Pages | 8223-30 |
| PubMed ID | 19843852 | Mgi Jnum | J:153955 |
| Mgi Id | MGI:4366648 | Doi | 10.1158/0008-5472.CAN-09-2166 |
| Citation | Weissman B, et al. (2009) Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer. Cancer Res 69(21):8223-30 |
| abstractText | There is increasing evidence that alterations in chromatin remodeling play a significant role in human disease. The SWI/SNF chromatin remodeling complex family mobilizes nucleosomes and functions as a master regulator of gene expression and chromatin dynamics whose functional specificity is driven by combinatorial assembly of a central ATPase and association with 10 to 12 unique subunits. Although the biochemical consequence of SWI/SNF in model systems has been extensively reviewed, the present article focuses on the evidence linking SWI/SNF perturbations to cancer initiation and tumor progression in human disease. |
