| First Author | Konjar S | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 11 | Pages | 2201-6 |
| PubMed ID | 20338168 | Mgi Jnum | J:172943 |
| Mgi Id | MGI:5009356 | Doi | 10.1016/j.febslet.2010.03.031 |
| Citation | Konjar S, et al. (2010) Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages. FEBS Lett 584(11):2201-6 |
| abstractText | Macrophages play a key role in innate immune response to pathogens and in tissue homeostasis, inflammation and repair. A serpin A3G (SpiA3G) is highly induced in classically activated macrophages. We show increased localization of SpiA3G in the nucleolus and co-localization with cathepsin L, upon classical, but not alternative activation of macrophages. Despite the increased expression of cathepsin L in the nuclei of classically activated macrophages, no cathepsin activity was detected. Since only pro-inflammatory, but not anti-inflammatory stimuli induce increased nucleolar localization of SpiA3G, we propose that SpiA3g translocation into the nucleolus is important in host defense against pathogens. |
