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Publication : The transcriptional landscape of the mammalian genome.

First Author  Carninci P Year  2005
Journal  Science Volume  309
Issue  5740 Pages  1559-63
PubMed ID  16141072 Mgi Jnum  J:99680
Mgi Id  MGI:3583429 Doi  10.1126/science.1112014
Citation  The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) (2005) The Transcriptional Landscape of the Mammalian Genome. Science 309(5740):1559-1563
abstractText  This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
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