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Protein Coding Gene : Fgf18 fibroblast growth factor 18

Primary Identifier  MGI:1277980 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  14172
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Acts upstream of or within several processes, including positive regulation of chondrocyte differentiation; positive regulation of signal transduction; and skeletal system development. Predicted to be located in nucleolus. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; musculoskeletal system; and sensory organ. Orthologous to human FGF18 (fibroblast growth factor 18).
PHENOTYPE: Homozygotes for targeted null mutations die perinatally and exhibit impaired proliferation and differentiation of osteoblasts, shortened and thickened long bones, and delayed ossification of the calvarium and long bones. [provided by MGI curators]
  • synonyms:
  • MGI:2441946,
  • D130055P09Rik,
  • FGF-18,
  • RIKEN cDNA D130055P09 gene,
  • Fgf18,
  • fibroblast growth factor 18

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

46 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

1 Driver For