| First Author | Wiesel M | Year | 2010 |
| Journal | J Immunol | Volume | 185 |
| Issue | 9 | Pages | 5188-97 |
| PubMed ID | 20881183 | Mgi Jnum | J:165190 |
| Mgi Id | MGI:4836427 | Doi | 10.4049/jimmunol.1001990 |
| Citation | Wiesel M, et al. (2010) Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses. J Immunol 185(9):5188-97 |
| abstractText | The mechanisms of how Th cells promote CD8(+) T cell responses during viral infections are largely unknown. In this study, we unraveled the mechanisms of T cell help for CD8(+) T cell responses during vaccinia virus infection. Our results demonstrate that Th cells promote vaccinia virus-specific CD8(+) T cell responses via two interconnected synergistic pathways: First, CD40L expressed by activated CD4(+) T cells instructs dendritic cells to produce bioactive IL-12p70, which is directly sensed by Ag-specific CD8(+) T cells, resulting in increased IL-2Ralpha expression. Second, Th cells provide CD8(+) T cells with IL-2, thereby enhancing their survival. Thus, Th cells are at the center of an important communication loop with a central role for IL-2/IL-2R and bioactive IL-12. |
