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Publication : Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling.

First Author  Zhang L Year  2018
Journal  Nat Commun Volume  9
Issue  1 Pages  4722
PubMed ID  30413707 Mgi Jnum  J:267918
Mgi Id  MGI:6267924 Doi  10.1038/s41467-018-06462-0
Citation  Zhang L, et al. (2018) Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling. Nat Commun 9(1):4722
abstractText  Excess caloric intake results in increased fat accumulation and an increase in energy expenditure via diet-induced adaptive thermogenesis; however, the underlying mechanisms controlling these processes are unclear. Here we identify the neuropeptide FF receptor-2 (NPFFR2) as a critical regulator of diet-induced thermogenesis and bone homoeostasis. Npffr2(-/-) mice exhibit a stronger bone phenotype and when fed a HFD display exacerbated obesity associated with a failure in activating brown adipose tissue (BAT) thermogenic response to energy excess, whereas the activation of cold-induced BAT thermogenesis is unaffected. NPFFR2 signalling is required to maintain basal arcuate nucleus NPY mRNA expression. Lack of NPFFR2 signalling leads to a decrease in BAT thermogenesis under HFD conditions with significantly lower UCP-1 and PGC-1alpha levels in the BAT. Together, these data demonstrate that NPFFR2 signalling promotes diet-induced thermogenesis via a novel hypothalamic NPY-dependent circuitry thereby coupling energy homoeostasis with energy partitioning to adipose and bone tissue.
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