| First Author | Murray MP | Year | 2022 |
| Journal | Cell Rep | Volume | 38 |
| Issue | 2 | Pages | 110209 |
| PubMed ID | 35021099 | Mgi Jnum | J:322567 |
| Mgi Id | MGI:6879537 | Doi | 10.1016/j.celrep.2021.110209 |
| Citation | Murray MP, et al. (2022) Stimulation of a subset of natural killer T cells by CD103(+) DC is required for GM-CSF and protection from pneumococcal infection. Cell Rep 38(2):110209 |
| abstractText | Innate-like T cells, including invariant natural killer T cells, mucosal-associated invariant T cells, and gammadelta T cells, are present in various barrier tissues, including the lung, where they carry out protective responses during infections. Here, we investigate their roles during pulmonary pneumococcal infection. Following infection, innate-like T cells rapidly increase in lung tissue, in part through recruitment, but T cell antigen receptor activation and cytokine production occur mostly in interleukin-17-producing NKT17 and gammadelta T cells. NKT17 cells are preferentially located within lung tissue prior to infection, as are CD103(+) dendritic cells, which are important both for antigen presentation to NKT17 cells and gammadelta T cell activation. Whereas interleukin-17-producing gammadelta T cells are numerous, granulocyte-macrophage colony-stimulating factor is exclusive to NKT17 cells and is required for optimal protection. These studies demonstrate how particular cellular interactions and responses of functional subsets of innate-like T cells contribute to protection from pathogenic lung infection. |
