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Publication : Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells.

First Author  Wortham M Year  2012
Journal  Cancer Discov Volume  2
Issue  6 Pages  492-4
PubMed ID  22684456 Mgi Jnum  J:193062
Mgi Id  MGI:5467475 Doi  10.1158/2159-8290.CD-12-0182
Citation  Wortham M, et al. (2012) Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells. Cancer Discov 2(6):492-4
abstractText  The mechanisms whereby medulloblastoma stem cells coordinate tumor propagation are poorly understood. Using microarray analysis, Corno and colleagues draw parallels and distinctions between medulloblastoma stem cells from the Ptch(+/-) mouse and normal neural stem cells, identifying Ebf3 as a cancer stem cell-specific transcript critical for tumor growth.
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