First Author | Wortham M | Year | 2012 |
Journal | Cancer Discov | Volume | 2 |
Issue | 6 | Pages | 492-4 |
PubMed ID | 22684456 | Mgi Jnum | J:193062 |
Mgi Id | MGI:5467475 | Doi | 10.1158/2159-8290.CD-12-0182 |
Citation | Wortham M, et al. (2012) Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells. Cancer Discov 2(6):492-4 |
abstractText | The mechanisms whereby medulloblastoma stem cells coordinate tumor propagation are poorly understood. Using microarray analysis, Corno and colleagues draw parallels and distinctions between medulloblastoma stem cells from the Ptch(+/-) mouse and normal neural stem cells, identifying Ebf3 as a cancer stem cell-specific transcript critical for tumor growth. |