| First Author | Olson JA | Year | 2013 |
| Journal | Immunity | Volume | 38 |
| Issue | 6 | Pages | 1250-60 |
| PubMed ID | 23746652 | Mgi Jnum | J:207586 |
| Mgi Id | MGI:5559143 | Doi | 10.1016/j.immuni.2013.05.009 |
| Citation | Olson JA, et al. (2013) Effector-like CD8(+) T cells in the memory population mediate potent protective immunity. Immunity 38(6):1250-60 |
| abstractText | The CD8(+) memory T cell population is heterogeneous, and it is unclear which subset(s) optimally mediate the central goal of the immune system-protection against infection. Here we investigate the protective capacities of CD8(+) T cell subsets present at the memory stage of the immune response. We show that a population of CD8(+) T cells bearing markers associated with effector cells (KLRG1(hi), CD27(lo), T-bet(hi), Eomes(lo)) persisted to the memory phase and provided optimal control of Listeria monocytogenes and vaccinia virus, despite weak recall proliferative responses. After antigen-specific boosting, this population formed the predominant secondary memory subset and maintained superior pathogen control. The effector-like memory subset displayed a distinct pattern of tissue distribution and localization within the spleen, and their enhanced capacity to eliminate Listeria involved specialized utilization of cytolysis. Together, these data suggest that long-lived effector CD8(+) T cells are optimal for protective immunity against certain pathogens. |
