| Primary Identifier | IPR034392 | Type | Domain |
| Short Name | TatSF1-like_RRM1 |
| description | This entry represents the RNA recognition motif 1 (RRM1) of Tat-SF1, which interacts with components of both the transcription and splicing machineries []. It has been shown to be a cofactor for human immunodeficiency virus-type 1 (HIV-1) Tat, which stimulates transcription elongation of HIV-1 through a series of events termed Tat transactivation [, ]. It contains two RNA recognition motifs (RRMs) and a highly acidic carboxyl-terminal half. Proteins containing this domain also include Cus2, a yeast homologue of human Tat-SF1. Cus2 interacts with U2 snRNA and Prp11, a subunit of the conserved splicing factor SF3a []. Like Tat-SF1, Cus2 contains two RRMs. |
