| First Author | Matloubian M | Year | 2000 |
| Journal | Nat Immunol | Volume | 1 |
| Issue | 4 | Pages | 298-304 |
| PubMed ID | 11017100 | Mgi Jnum | J:65117 |
| Mgi Id | MGI:1891794 | Doi | 10.1038/79738 |
| Citation | Matloubian M, et al. (2000) A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol 1(4):298-304 |
| abstractText | We describe a protein with the hallmarks of a chemokine, designated CXCL16, that is made by dendritic cells (DCs) in lymphoid organ T cell zones and by cells in the splenic red pulp. CXCL16 contains a transmembrane domain and both membrane-bound and soluble forms are produced. Naive CD8 T cells, natural killer T cells and a subset of memory CD4 T cells bind CXCL16, and activated T cells migrated chemotactically to the soluble chemokine. By expression cloning, Bonzo (also known as STRL33 and TYMSTR) was identified as a CXCL16 receptor. CXCL16 may function in promoting interactions between DCs and CD8 T cells and in guiding T cell movements in the splenic red pulp. CXCL16 was also found in the thymic medulla and in some nonlymphoid tissues, indicating roles in thymocyte development and effector T cell trafficking. |
