| First Author | Satoskar A | Year | 1997 |
| Journal | J Infect Dis | Volume | 176 |
| Issue | 6 | Pages | 1649-52 |
| PubMed ID | 9395385 | Mgi Jnum | J:44291 |
| Mgi Id | MGI:1099677 | Doi | 10.1086/517348 |
| Citation | Satoskar A, et al. (1997) Gammadelta T cells are not essential for control of cutaneous Leishmania major infection in genetically resistant C57BL/6 mice. J Infect Dis 176(6):1649-52 |
| abstractText | As gammadelta T cells are believed to be involved in host defense against Leishmania major, the role of gammadelta T cells in immunity against this parasite was investigated. The growth of L. major was measured in alphabeta (T cell receptor [TCR] alpha -/-) and gammadelta (TCR delta -/-) TCR-deficient C57BL/6 mice and compared with growth in control (C57BL/6) mice. While TCR alpha -/- mice developed nonhealing lesions containing large numbers of parasites following L. major infection, TCR delta -/- and C57BL/6 mice effectively controlled the infection. Following in vitro stimulation, lymph node cells from C57BL/6 mice produced significantly more interferon (IFN)-gamma than those from TCR delta -/- mice during early and late phases of infection; however, both produced similar levels of IFN-gamma at postinfection week 6. Culture supernatants from both TCR delta -/- and C57BL/6 mice contained interleukin-4, at postinfection week 2 only. These results indicate that gammadelta CD3 T cells are not essential for mediating protection against cutaneous L. major infection in C57BL/6 mice. |
