| First Author | Leamy LJ | Year | 2008 |
| Journal | Heredity (Edinb) | Volume | 101 |
| Issue | 6 | Pages | 518-26 |
| PubMed ID | 18685568 | Mgi Jnum | J:277088 |
| Mgi Id | MGI:6307444 | Doi | 10.1038/hdy.2008.79 |
| Citation | Leamy LJ, et al. (2008) A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape. Heredity (Edinb) 101(6):518-26 |
| abstractText | Genomic imprinting refers to the pattern of monoallelic parent-of-origin-dependent gene expression where one of the two alleles at a locus is expressed and the other silenced. Although some genes in mice are known to be imprinted, the true scope of imprinting and its impact on the genetic architecture of a wide range of morphometric traits is mostly unknown. We therefore searched for quantitative trait loci (QTL) exhibiting imprinting effects on mandible size and shape traits in a large F(3) population of mice originating from an intercross of the LG/J (Large) and SM/J (Small) inbred strains. We discovered a total of 51 QTL affecting mandible size and shape, 6 of which exhibited differences between reciprocal heterozygotes, the usual signature of imprinting effects. However, our analysis showed that only one of these QTL (affecting mandible size) exhibited a pattern consistent with true imprinting effects, whereas reciprocal heterozygote differences in the other five all were due to maternal genetic effects. We concluded that genomic imprinting has a negligible effect on these specific morphometric traits, and that maternal genetic effects may account for many of the previously reported instances of apparent genomic imprinting. |
