| First Author | Thurlow LR | Year | 2018 |
| Journal | Cell Host Microbe | Volume | 24 |
| Issue | 2 | Pages | 261-270.e4 |
| PubMed ID | 30057172 | Mgi Jnum | J:281452 |
| Mgi Id | MGI:6284893 | Doi | 10.1016/j.chom.2018.07.001 |
| Citation | Thurlow LR, et al. (2018) Peroxisome Proliferator-Activated Receptor gamma Is Essential for the Resolution of Staphylococcus aureus Skin Infections. Cell Host Microbe 24(2):261-270.e4 |
| abstractText | Skin/soft tissue infections (SSTIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) represent serious healthcare burdens worldwide. The host initially controls these infections with a pro-inflammatory infiltrate. However, once established, MRSA viability remains constant. To clear established MRSA SSTIs, the host must transition into the post-inflammatory resolution phase marked by infiltration of alternatively activated macrophages. Here we show that the host nuclear receptor, peroxisome proliferation activator receptor gamma (PPARgamma), is essential for this transition and MRSA clearance. Chemical PPARgamma inhibition or genetic ablation of PPARgamma in myeloid cells results in an extended inflammatory phase and exacerbated MRSA SSTIs. Conversely, treating mice with PPARgamma agonists hastens the onset of the resolution phase and improves MRSA clearance in a myeloid-dependent fashion. The resolving fibrotic abscess lacks abundant glucose and oxygen but is replete with antimicrobial peptides, which together contribute to MRSA clearance. Thus, PPARgamma agonists may serve as viable treatment options for complicated MRSA SSTIs. |
