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Publication : Genetic linkage analysis of collagen-induced arthritis in the mouse.

First Author  Jirholt J Year  1998
Journal  Eur J Immunol Volume  28
Issue  10 Pages  3321-8
PubMed ID  9808201 Mgi Jnum  J:50472
Mgi Id  MGI:1306721 Doi  10.1002/(SICI)1521-4141(199810)28:10<3321::AID-IMMU3321>3.0.CO;2-M
Citation  Jirholt J, et al. (1998) Genetic linkage analysis of collagen-induced arthritis in the mouse. Eur J Immunol 28(10):3321-8
abstractText  The genetic susceptibility to collagen-induced arthritis (CIA) in mice, the most commonly used model for rheumatoid arthritis, has been analyzed. The highly susceptible B10.RIII strain was crossed with the resistant RIIIS/J strain and the F2 intercross mice were subjected to genomic screening using microsatellite markers. These strains share the MHC region on chromosome 17, known to be of importance in CIA (this locus is named Mcia1). The same cross has earlier been used to map the major genes outside the MHC controlling chronic relapsing experimental allergic encephalomyelitis (EAE). It was found that the major locus controlling CIA (Mcia2; lod 4.12) was located on chromosome 3 in the same region as one of the major loci controlling EAE (Eae3). The linkage was reproduced in a mouse strain in which the locus was isolated on the B10.RIII background at the N412 generation. A second putative locus was identified on chromosome 13 (lod 3.13). The present finding identifies new loci outside the MHC controlling CIA and provides evidence that mouse CIA is controlled by polymorphic genes.
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