| First Author | Berquam-Vrieze KE | Year | 2012 |
| Journal | Genesis | Volume | 50 |
| Issue | 2 | Pages | 112-8 |
| PubMed ID | 21898766 | Mgi Jnum | J:187874 |
| Mgi Id | MGI:5438475 | Doi | 10.1002/dvg.20798 |
| Citation | Berquam-Vrieze KE, et al. (2012) Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1. Genesis 50(2):112-8 |
| abstractText | The Notch1 receptor plays a critical role in cell fate decisions during development. Activation of Notch signaling has been implicated in several types of cancer, particularly T-cell acute lymphoblastic leukemia (T-ALL). Consequently, several transgenic mouse strains have been made to study the role of Notch1 in T-ALL. However, the existing Notch1 transgenic lines mimic a translocation event found in only approximately 1% of T-ALL cases. Here we describe three novel NOTCH1 transgenic mouse strains that have Cre-inducible expression of the entire human NOTCH1 locus, each possessing a common mutation found in T-ALL. Unlike existing Notch1 transgenic strains, these NOTCH1 transgenic strains express full-length receptors from an endogenous human promoter that should be susceptible to a number of Notch antagonists that have recently been developed. These strains will allow researchers to modulate Notch signaling to study both normal development and cancer biology. |
