Experiment Id | GSE214393 | Name | Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol |
Experiment Type | RNA-Seq | Study Type | WT vs. Mutant |
Source | GEO | Curation Date | 2023-08-25 |
description | SURF4 is a cargo receptor that has been implicated in the intracellular trafficking of PCSK9 and APOB - proteins involved in cholesterol transport and metabolism. We generated hepatic SURF4-deficient mice (Surf4(fl/fl) Alb-Cre+) to investigate the physiologic role of SURF4 in vivo |