Primary Identifier | MGI:1859285 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 53624 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cell adhesion molecule binding activity; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including bicellular tight junction assembly; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; and negative regulation of protein-containing complex assembly. Located in several cellular components, including apicolateral plasma membrane; basolateral plasma membrane; and lateral plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; olfactory epithelium; respiratory system; and urinary system. Orthologous to human CLDN7 (claudin 7). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased body size, weight, and length; abnormal potassium, chloride, and sodium ion excretion; chronic dehydration; and postnatal lethality by P12. [provided by MGI curators] |