| First Author | Reiley WW | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 4 | Pages | 411-7 |
| PubMed ID | 16501569 | Mgi Jnum | J:112392 |
| Mgi Id | MGI:3656194 | Doi | 10.1038/ni1315 |
| Citation | Reiley WW, et al. (2006) Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol 7(4):411-7 |
| abstractText | T cell receptor signaling is essential for the generation and maturation of T lymphocyte precursors. Here we identify the deubiquitinating enzyme CYLD as a positive regulator of proximal T cell receptor signaling in thymocytes. CYLD physically interacted with active Lck and promoted recruitment of active Lck to its substrate, Zap70. CYLD also removed both Lys 48- and Lys 63-linked polyubiquitin chains from Lck. Because of a cell-autonomous defect in T cell development, CYLD-deficient mice had substantially fewer mature CD4(+) and CD8(+) single-positive thymocytes and peripheral T cells. |
