| Primary Identifier | MGI:1100863 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 16648 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within protein transport. Predicted to be located in cytoplasm. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Orthologous to human KPNA3 (karyopherin subunit alpha 3). PHENOTYPE: Mice homozygous for a null mutation are viable and fertile. Homozygous knockout leads to increased susceptibility to influenza A virus-induced morbidity and mortality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
