Primary Identifier | MGI:3045315 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 329547 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in several processes, including defense response to other organism; lipopolysaccharide-mediated signaling pathway; and negative regulation of cytokine production. Predicted to act upstream of or within immune system process. Located in cytoplasm. Human ortholog(s) of this gene implicated in Crohn's disease. Orthologous to human BPI (bactericidal permeability increasing protein). PHENOTYPE: Mice homozygous for a null allele display increased susceptibility to induced colitis and impaired IL22 induction. [provided by MGI curators] |