Primary Identifier | MGI:99259 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 17179 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Is expressed in brain; gonad; hemolymphoid system gland; and intestine. Orthologous to human MATK (megakaryocyte-associated tyrosine kinase). PHENOTYPE: Homozygous mice are viable and fertile and appear normal. Unchallenged mutant mice exhibit no hematopoietic defects. SPKLS cell numbers are elevated. IL-7 induced BM cell proliferation and pre-B cell colony formation are enhanced. Antigen induced IFN-gamma secretion is reduced. [provided by MGI curators] |