| First Author | Föger N | Year | 2006 |
| Journal | Science | Volume | 313 |
| Issue | 5788 | Pages | 839-42 |
| PubMed ID | 16902139 | Mgi Jnum | J:111593 |
| Mgi Id | MGI:3654559 | Doi | 10.1126/science.1130563 |
| Citation | Foger N, et al. (2006) Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science 313(5788):839-42 |
| abstractText | The evolutionarily conserved actin-related protein (Arp2/3) complex is a key component of actin filament networks that is dynamically regulated by nucleation-promoting and inhibitory factors. Although much is known about actin assembly, the physiologic functions of inhibitory proteins are unclear. We generated coronin 1-/- mice and found that coronin 1 exerted an inhibitory effect on cellular steady-state F-actin formation via an Arp2/3-dependent mechanism. Whereas coronin 1 was required for chemokine-mediated migration, it was dispensable for T cell antigen receptor functions in T cells. Moreover, actin dynamics, through a mitochondrial pathway, was linked to lymphocyte homeostasis. |
